| Code | Description | Comment | Version |
| ... | Source RFC 2046 | deprecated | added v2.6, removed after v2.8.2 |
| BASIC | ISDN PCM audio data | | added v2.3 |
| DICOM | Digital Imaging and Communications in Medicine | | added v2.3 |
| FAX | Facsimile data | | added v2.3 |
| GIF | Graphics Interchange Format | | added v2.3 |
| HTML | Hypertext Markup Language | | added v2.3 |
| JOT | Electronic ink data (Jot 1.0 standard) | | added v2.3 |
| JPEG | Joint Photographic Experts Group | | added v2.3 |
| Octet-stream | Uninterpreted binary data | | added v2.3 |
| PICT | PICT format image data | | added v2.3 |
| PostScript | PostScript program | | added v2.3 |
| RTF | Rich Text Format | | added v2.3 |
| SGML | Standard Generalized Markup Language (HL7 V2.3.1 and later) | | added v2.3.1 |
| TIFF | TIFF image data | | added v2.3 |
| x-hl7-cda-level-one | HL7 Clinical Document Architecture Level One document | Retained for backwards compatibility only as of v2.6 and CDA R 2. Preferred value is text/xml. | added v2.4 |
| XML | Extensible Markup Language (HL7 V2.3.1 and later) | | added v2.3.1 |
| … | Source RFC 2046 | deprecated | added v2.7.1, removed after v2.7.1 |